Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581242 | 0.96 | ALDH1A1 (0.40) | ALDH1A1TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL581795 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ATRPV4KCNN4 | |
| SCHEMBL581796 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ATRPV4KCNN4 | |
| SCHEMBL581709 | 0.89 | RIPK1 (0.39) | ALDH1A1MEN1KMT2ARIPK1GRM5 | |
| SCHEMBL580798 | 0.88 | ALDH1A1 (0.49) | ALDH1A1KMT2ATRPV4KCNN4 | |
| SCHEMBL3073129 | 0.88 | ALDH1A1 (0.49) | ALDH1A1KMT2ATRPV4KCNN4 | |
| SCHEMBL3062815 | 0.88 | ALDH1A1 (0.49) | ALDH1A1KMT2ATRPV4KCNN4 | |
| SCHEMBL586556 | 0.88 | RIPK1 (0.40) | ALDH1A1TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL581776 | 0.85 | MEN1 (0.44) | ALDH1A1MEN1KMT2ARIPK1L3MBTL1 | |
| SCHEMBL3076421 | 0.85 | MEN1 (0.44) | ALDH1A1MEN1KMT2ARIPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |