Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23289929 | 0.89 | HDAC1 (0.64) | HDAC1HDAC6HDAC8NOTUMFFAR1 | |
| SCHEMBL1713754 | 0.81 | HDAC1 (0.53) | HDAC1HDAC6HDAC8CYP2D6ALDH1A1 | |
| SCHEMBL13309551 | 0.81 | HDAC1 (0.56) | HDAC1HDAC6HDAC8NOTUMFFAR1 | |
| SCHEMBL1713006 | 0.81 | CYP2D6 (0.56) | HDAC1HDAC6HDAC8NOTUMCYP2D6 | |
| SCHEMBL30733410 | 0.81 | HDAC1 (0.58) | HDAC1HDAC6HDAC8NOTUMFFAR1 | |
| SCHEMBL14623149 | 0.79 | FFAR1 (0.56) | HDAC1HDAC6HDAC8FFAR1CYP2D6 | |
| SCHEMBL1980590 | 0.79 | HDAC1 (0.68) | HDAC1HDAC6HDAC8FFAR1CYP2D6 | |
| SCHEMBL30733428 | 0.78 | HDAC1 (0.55) | HDAC1HDAC6HDAC8NOTUMFFAR1 | |
| SCHEMBL5578692 | 0.76 | SIGMAR1 (0.52) | HDAC1HDAC6NOTUMSIGMAR1DRD2 | |
| SCHEMBL30733424 | 0.76 | P2RY1 (0.54) | HDAC1HDAC6HDAC8FFAR1P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | HDAC1 2067/4885HDAC6 526/4885HDAC8 1532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.