Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25232223 | 0.87 | NPSR1 (0.33) | AKT1GAAEPHX1 | |
| SCHEMBL32687873 | 0.85 | NPSR1 (0.33) | AKT1BTK | |
| SCHEMBL22532934 | 0.82 | GAA (0.33) | AKT1BTKGAAEPHX1 | |
| SCHEMBL31252257 | 0.78 | AKT1 (0.37) | AKT1 | |
| SCHEMBL4397311 | 0.76 | CTSD (0.30) | — | |
| SCHEMBL25178779 | 0.74 | CTSD (0.31) | — | |
| SCHEMBL13387122 | 0.74 | MEN1 (0.40) | AKT1BTKGAAEPHX1 | |
| SCHEMBL25233110 | 0.73 | AKT1 (0.32) | AKT1BTK | |
| SCHEMBL25232707 | 0.73 | CTSD (0.33) | AKT1 | |
| SCHEMBL25233993 | 0.72 | CTSD (0.32) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | AKT1 3467/4885BTK 2204/4885GAA 2832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.