Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31282451 | 0.92 | DRD2 (0.37) | DDB1CRBNEEDSLC6A4DRD2 | |
| SCHEMBL30225615 | 0.89 | KHK (0.40) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31282297 | 0.87 | NMT1 (0.39) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31282427 | 0.85 | DRD2 (0.41) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31281909 | 0.85 | DRD2 (0.41) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31282708 | 0.83 | DRD2 (0.42) | DDB1CRBNSLC6A4DRD2GNRHR | |
| SCHEMBL31281895 | 0.82 | DRD2 (0.35) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31281965 | 0.82 | DRD2 (0.39) | DDB1CRBNSLC6A4DRD2GNRHR | |
| SCHEMBL29991433 | 0.82 | DDB1 (0.39) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31281914 | 0.81 | DRD2 (0.38) | DDB1CRBNSLC6A4DRD2GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519273-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215906-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | HANGZHOU JIJING PHARMACEUTICALTECHNOLOGY LIMITED (CN) | 2023-11-09 | — | — | WO | disclosed |