Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HPD | P32754 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31282297 | 0.93 | NMT1 (0.39) | KHKDDB1CRBNSLC6A4DRD2 | |
| SCHEMBL30733897 | 0.89 | DDB1 (0.40) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31282585 | 0.88 | DDB1 (0.38) | KHKDDB1CRBNSLC6A4DRD2 | |
| SCHEMBL31282427 | 0.87 | DRD2 (0.41) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL29991433 | 0.84 | DDB1 (0.39) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL26634973 | 0.83 | DDB1 (0.39) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL28650168 | 0.83 | NMT1 (0.40) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31281909 | 0.83 | DRD2 (0.41) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL30225575 | 0.82 | HDAC1 (0.40) | DDB1CRBNSLC6A4DRD2HPD | |
| SCHEMBL31282399 | 0.82 | DDB1 (0.38) | DDB1CRBNSLC6A4DRD2HPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121043-A1 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |