Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30734310 | 0.81 | TP53 (0.47) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL30734314 | 0.81 | XDH (0.48) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL27276581 | 0.77 | KDM4E (0.47) | MAPTGAA | |
| SCHEMBL30734304 | 0.75 | MAPT (0.57) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL17582804 | 0.75 | MAPT (0.57) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL17678160 | 0.75 | MAPT (0.57) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL11900769 | 0.75 | MAPT (0.57) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL4077406 | 0.74 | MAPK1 (0.62) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL2490062 | 0.72 | MAPT (0.57) | HCAR3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL8885726 | 0.72 | ALDH1A1 (0.59) | HCAR3MAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250399-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |