Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30734262 | 0.81 | HCAR3 (0.51) | TP53MAPTMAPK1MEN1KMT2A | |
| SCHEMBL30734264 | 0.79 | KDM4E (0.40) | MAPTL3MBTL1GAA | |
| SCHEMBL22043535 | 0.73 | KDM4E (0.46) | TP53MAPTRXFP1L3MBTL1GAA | |
| SCHEMBL1830727 | 0.73 | NPC1 (0.55) | MAPTMEN1KMT2APOLBHTT | |
| SCHEMBL1127050 | 0.73 | TDP1 (0.47) | MAPTMEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL30734314 | 0.72 | XDH (0.48) | TP53MAPTMAPK1MEN1KMT2A | |
| SCHEMBL29033804 | 0.72 | KCNJ1 (0.44) | MAPTMEN1KMT2APOLBKCNJ1 | |
| SCHEMBL17582804 | 0.72 | MAPT (0.57) | MAPTMAPK1MEN1KMT2AHCAR3 | |
| SCHEMBL11900769 | 0.72 | MAPT (0.57) | MAPTMAPK1MEN1KMT2AHCAR3 | |
| SCHEMBL17678160 | 0.72 | MAPT (0.57) | MAPTMAPK1MEN1KMT2AHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250399-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |