Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 6/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.35 |
| ▸ | WNT1 | P04628 | 4/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30910243 | 0.68 | MAP4K1 (0.40) | MAP4K1CDC7BMPR1BBMPR1AACVRL1 | |
| SCHEMBL27186723 | 0.67 | KRAS (0.36) | MAP4K1GSK3BDYRK1A | |
| SCHEMBL8337642 | 0.61 | GAA (0.38) | GAASMN1; SMN2 | |
| SCHEMBL30972386 | 0.61 | PRKCG (0.36) | KDM2BMAP4K1TLR8 | |
| SCHEMBL29985240 | 0.61 | MAP4K1 (0.37) | MAP4K1GSK3BDYRK1AWNT1PRKDC | |
| SCHEMBL17645606 | 0.60 | DGAT1 (0.36) | HTR2CDYRK1AKDR | |
| SCHEMBL30738992 | 0.60 | KRAS (0.33) | TGFBR1 | |
| SCHEMBL29099878 | 0.60 | HTR1A (0.37) | GAASMN1; SMN2 | |
| SCHEMBL16338504 | 0.60 | KDM4E (0.37) | — | |
| SCHEMBL22283892 | 0.60 | DYRK1A (0.39) | DYRK1AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561258-A | Novel substituted tricyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-02-13 | — | — | CN | disclosed |