Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30739083 | 0.88 | GRM2 (0.48) | GRM2ALDH1A1LMNAKLKB1NPC1 | |
| SCHEMBL20529831 | 0.86 | KLKB1 (0.52) | GRM2ALDH1A1LMNAKLKB1SMN1; SMN2 | |
| SCHEMBL30739122 | 0.85 | GRM2 (0.52) | GRM2ALDH1A1LMNAKLKB1NPC1 | |
| SCHEMBL1909166 | 0.85 | GRM2 (0.53) | GRM2ALDH1A1LMNAKLKB1NPC1 | |
| SCHEMBL2821953 | 0.84 | LMNA (0.54) | GRM2ALDH1A1LMNAKLKB1NPC1 | |
| SCHEMBL28595790 | 0.84 | ESR1 (0.55) | GRM2ALDH1A1LMNAKLKB1NPC1 | |
| SCHEMBL30739156 | 0.84 | KLKB1 (0.51) | GRM2LMNAKLKB1SMN1; SMN2 | |
| SCHEMBL30739164 | 0.84 | KLKB1 (0.51) | GRM2LMNAKLKB1SMN1; SMN2 | |
| SCHEMBL30739075 | 0.83 | GRM2 (0.48) | GRM2ALDH1A1LMNAKLKB1NPC1 | |
| SCHEMBL30739056 | 0.83 | KLKB1 (0.50) | GRM2ALDH1A1LMNAKLKB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-120051460-A | Plasma kallikrein inhibitors | 瑞泽路特有限公司 | 2025-05-27 | — | — | CN | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |