Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20529831 | 0.96 | KLKB1 (0.52) | KLKB1GRM2MAPTTDP1TSHR | |
| SCHEMBL30739164 | 0.94 | KLKB1 (0.51) | KLKB1GRM2MAPTTDP1TSHR | |
| SCHEMBL30739156 | 0.94 | KLKB1 (0.51) | KLKB1GRM2MAPTTDP1TSHR | |
| SCHEMBL30739032 | 0.90 | KLKB1 (0.50) | KLKB1GRM2LMNAELANEITK | |
| SCHEMBL30739112 | 0.86 | GRM2 (0.44) | KLKB1GRM2MAPTTDP1TSHR | |
| SCHEMBL30739083 | 0.85 | GRM2 (0.48) | KLKB1GRM2MAPTSMN1; SMN2LMNA | |
| SCHEMBL1909166 | 0.84 | GRM2 (0.53) | KLKB1GRM2LMNAMAPK1ALDH1A1 | |
| SCHEMBL30739047 | 0.84 | GRM2 (0.43) | KLKB1GRM2MAPTTDP1TSHR | |
| SCHEMBL2821953 | 0.83 | LMNA (0.54) | KLKB1GRM2MAPTTDP1SMN1; SMN2 | |
| SCHEMBL28595790 | 0.83 | ESR1 (0.55) | KLKB1GRM2TDP1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-120051460-A | Plasma kallikrein inhibitors | 瑞泽路特有限公司 | 2025-05-27 | — | — | CN | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |