SCHEMBL20529831

SCHEMBL20529831

CCOC(=O)c1cnn(Cc2ccc(C#N)cc2)c1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KLKB1 P03952 3/20 0.52
▸ MAPT P10636 2/20 0.48
▸ TDP1 Q9NUW8 2/20 0.48
▸ GRM2 Q14416 1/20 0.48
▸ LMNA P02545 2/20 0.47
▸ TSHR P16473 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ CYP11B1 P15538 2/20 0.46
▸ CYP11B2 P19099 2/20 0.46
▸ ELANE P08246 2/20 0.44
▸ ITK Q08881 1/20 0.44
▸ CYP19A1 P11511 2/20 0.43
▸ SCD O00767 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30739156 0.98 KLKB1 (0.51) KLKB1MAPTTDP1GRM2LMNA
SCHEMBL30739164 0.98 KLKB1 (0.51) KLKB1MAPTTDP1GRM2LMNA
SCHEMBL30739056 0.96 KLKB1 (0.50) KLKB1MAPTTDP1GRM2LMNA
SCHEMBL30739112 0.89 GRM2 (0.44) KLKB1MAPTTDP1GRM2LMNA
SCHEMBL30739083 0.88 GRM2 (0.48) KLKB1MAPTGRM2LMNASMN1; SMN2
SCHEMBL1909166 0.87 GRM2 (0.53) KLKB1GRM2LMNAMAPK1ALDH1A1
SCHEMBL30739047 0.87 GRM2 (0.43) KLKB1MAPTTDP1GRM2LMNA
SCHEMBL30739032 0.86 KLKB1 (0.50) KLKB1GRM2LMNAELANEITK
SCHEMBL2821953 0.86 LMNA (0.54) KLKB1MAPTTDP1GRM2LMNA
SCHEMBL28595790 0.86 ESR1 (0.55) KLKB1TDP1GRM2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606548-B2 Fungicidal oxadiazoles FMC CORPORATION (US) 2026-04-21 — — US disclosed
EP-4562015-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME Cedilla Therapeutics, Inc. (US) 2025-06-04 — — EP disclosed
US-20240166638-A1 FUNGICIDAL OXADIAZOLES FMC CORP (US) 2024-05-23 — — US disclosed
CN-118047771-A Fungicidal oxadiazoles FMC公司 2024-05-17 — — CN disclosed
CN-118047729-A Fungicidal oxadiazoles FMC公司 2024-05-17 — — CN disclosed
EP-4361150-A2 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC Corporation (US) 2024-05-01 — — EP disclosed
US-20240090503-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION 2024-03-21 — — US disclosed
CN-110650956-B Fungicidal oxadiazoles FMC公司 2024-03-08 — — CN disclosed
WO-2024026481-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 — — WO disclosed
EP-4262396-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION (US) 2023-10-25 — — EP disclosed
US-20200315176-A1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2020-10-08 — — US disclosed
US-20200148672-A1 FUNGICIDAL OXADIAZOLES FMC CORPORATION 2020-05-14 — — US disclosed
EP-3644743-A1 FUNGICIDAL COMPOSITIONS Syngenta Participations AG (CH) 2020-05-06 — — EP disclosed
CN-110799035-A Fungicidal compositions 先正达参股股份有限公司 2020-02-14 — — CN disclosed
EP-3606920-A1 FUNGICIDAL OXADIAZOLES FMC Corporation (US) 2020-02-12 — — EP disclosed
CN-110650956-A Fungicidal oxadiazoles FMC公司 2020-01-03 — — CN disclosed
WO-2019011926-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-01-17 — — WO disclosed
WO-2019011926-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-01-17 — — WO disclosed
WO-2019002151-A1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2019-01-03 — — WO disclosed
WO-2018187553-A1 FUNGICIDAL OXADIAZOLES FMC CORPORATION (US) 2018-10-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240166638-A1 FUNGICIDAL OXADIAZOLES OXA1L, NOX1, TH KLKB1 3605/4885MAPT 224/4885TDP1 521/4885
US-12606548-B2 Fungicidal oxadiazoles AOC2, AOC3, MT-CO3 KLKB1 4747/4885MAPT 1233/4885TDP1 3380/4885
US-20200148672-A1 FUNGICIDAL OXADIAZOLES OXA1L, NOX1, TH KLKB1 3605/4885MAPT 224/4885TDP1 521/4885
US-20240090503-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES NOX1, TH, NOX3 KLKB1 4112/4885MAPT 154/4885TDP1 906/4885
US-20200315176-A1 FUNGICIDAL COMPOSITIONS CYP51A1, CYP4X1, CYP1B1 KLKB1 3768/4885MAPT 2069/4885TDP1 601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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