SCHEMBL30740576

SCHEMBL30740576

CCOC(=O)Cc1nc(Br)sc1C(=O)OCC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
HSD17B10 Q99714 3/20 0.47
CYP1A2 P05177 1/20 0.45
HPGD P15428 3/20 0.42
LMNA P02545 1/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 1/20 0.42
DHODH Q02127 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KMT2A Q03164 2/20 0.40
TSHR P16473 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CDC7 O00311 3/20 0.40
DBF4 Q9UBU7 3/20 0.40
TRPM8 Q7Z2W7 2/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2692004 0.86 ALDH1A1 (0.50) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL2719635 0.86 NPC1 (0.49) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL1921091 0.85 ALDH1A1 (0.49) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL23214292 0.85 LMNA (0.49) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL2885576 0.84 ALDH1A1 (0.47) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL2823911 0.83 ALDH1A1 (0.48) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL2720641 0.83 ALDH1A1 (0.63) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL15581984 0.83 ALDH1A1 (0.46) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL2720481 0.83 ALDH1A1 (0.46) ALDH1A1HSD17B10CYP1A2HPGDLMNA
SCHEMBL5552417 0.83 ALDH1A1 (0.46) ALDH1A1HSD17B10CYP1A2HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117229281-A Di-parallel ring derivative regulator, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-12-15 CN disclosed