SCHEMBL30746406

SCHEMBL30746406

Cc1c(N)cccc1Cc1ccnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1F

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 1/20 0.36
KCNH2 Q12809 2/20 0.35
ESR1 P03372 1/20 0.35
MPO P05164 1/20 0.32
AOC3 Q16853 1/20 0.30
GUCY1A1 Q02108 1/20 0.30
GUCY1B1 Q02153 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26985322 1.00 SSTR4 (0.36) SSTR4KCNH2ESR1MPOAOC3
SCHEMBL26985281 0.95 SSTR4 (0.35) SSTR4KCNH2ESR1MPO
SCHEMBL26984912 0.88 SSTR4 (0.35) SSTR4
SCHEMBL26984998 0.84 ALDH1A1 (0.36) SSTR4
SCHEMBL30746376 0.80 SSTR4 (0.36) SSTR4
SCHEMBL30746578 0.78 SSTR4 (0.35) SSTR4
SCHEMBL31613366 0.78 SSTR4 (0.35) SSTR4
SCHEMBL26984960 0.78 SSTR4 (0.35) SSTR4
SCHEMBL26985097 0.78 SSTR4 (0.45) SSTR4AOC3
SCHEMBL31686074 0.78 GPR52 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120129678-A Mitogen-activated protein kinase (MEK) inhibitors 耐斯泰德医疗公司 2025-06-10 CN disclosed
EP-4551558-A2 MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS Nested Therapeutics, Inc. (US) 2025-05-14 EP disclosed
WO-2024010925-A2 MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS NESTED THERAPEUTICS, INC. (US) 2024-01-11 WO disclosed