SCHEMBL26985281

SCHEMBL26985281

Cc1c(N)cccc1Cc1ccnc(N(C(=O)O)C(=O)OC(C)(C)C)c1F

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 1/20 0.35
ESR1 P03372 1/20 0.34
KCNH2 Q12809 1/20 0.34
MPO P05164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30746406 0.95 SSTR4 (0.36) SSTR4ESR1KCNH2MPO
SCHEMBL26985322 0.95 SSTR4 (0.36) SSTR4ESR1KCNH2MPO
SCHEMBL26984912 0.83 SSTR4 (0.35) SSTR4
SCHEMBL26984998 0.81 ALDH1A1 (0.36) SSTR4
SCHEMBL27131001 0.81 SSTR4 (0.34) SSTR4
SCHEMBL26985409 0.79 GPR52 (0.40)
SCHEMBL26985318 0.79 KMO (0.36) SSTR4
SCHEMBL26985019 0.77 SSTR4 (0.40) SSTR4
SCHEMBL31613366 0.76 SSTR4 (0.35) SSTR4
SCHEMBL30746376 0.76 SSTR4 (0.36) SSTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024010925-A2 MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS NESTED THERAPEUTICS, INC. (US) 2024-01-11 WO disclosed