SCHEMBL30746435

SCHEMBL30746435

C#Cc1cnc(Nc2cncc(Cc3ccnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c3F)c2C)c(F)c1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 1/20 0.31
SYK P43405 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26985213 1.00 GPR119 (0.31) GPR119SYK
SCHEMBL26985331 0.90
SCHEMBL30746414 0.90
SCHEMBL30746591 0.89 SYK (0.35) SYK
SCHEMBL26985124 0.85 SYK (0.34) SYK
SCHEMBL26985220 0.84 GPR119 (0.41) GPR119
SCHEMBL30746430 0.84 GPR119 (0.41) GPR119
SCHEMBL26984989 0.83 MKNK1 (0.34) SYK
SCHEMBL30746646 0.83 MKNK1 (0.34) SYK
SCHEMBL26985146 0.83 SYK (0.35) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4551558-A2 MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS Nested Therapeutics, Inc. (US) 2025-05-14 EP disclosed
WO-2024010925-A2 MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS NESTED THERAPEUTICS, INC. (US) 2024-01-11 WO disclosed