Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746591 | 0.96 | SYK (0.35) | SYKS1PR3IRAK4ACVR1BTGFBR1 | |
| SCHEMBL26985070 | 0.87 | NUDT1 (0.40) | SYKS1PR3ACVR1BTGFBR1ACVRL1 | |
| SCHEMBL30746435 | 0.85 | GPR119 (0.31) | SYK | |
| SCHEMBL26984982 | 0.85 | FPR2 (0.36) | — | |
| SCHEMBL26985213 | 0.85 | GPR119 (0.31) | SYK | |
| SCHEMBL26985057 | 0.84 | DHODH (0.38) | — | |
| SCHEMBL30746582 | 0.84 | DHODH (0.38) | — | |
| SCHEMBL26985331 | 0.83 | — | — | |
| SCHEMBL30746414 | 0.83 | — | — | |
| SCHEMBL30746646 | 0.82 | MKNK1 (0.34) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |