Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863204 | 0.77 | CHKA (0.43) | KDM4EUSP2 | |
| SCHEMBL4869797 | 0.75 | ALDH1A1 (0.43) | KDM4EUSP2 | |
| SCHEMBL4138501 | 0.72 | ALDH1A1 (0.31) | KDM4ECHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL7400905 | 0.72 | ADRB1 (0.52) | KDM4ECHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL21247013 | 0.71 | ADRB1 (0.50) | CHRM2CHRM4CHRM1CHRM3CYP2D6 | |
| SCHEMBL12082315 | 0.68 | ADRB1 (0.53) | KDM4EUSP2 | |
| SCHEMBL22816129 | 0.68 | AKR1C3 (0.42) | USP2CYP2D6 | |
| SCHEMBL2692445 | 0.68 | MAPT (0.59) | KDM4EUSP2 | |
| SCHEMBL19468891 | 0.68 | CHKA (0.59) | CYP2D6 | |
| SCHEMBL16400663 | 0.68 | KDM4E (0.53) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024217348-A1 | KIF18A INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 南京同诺康医药科技有限公司 | 2024-10-24 | — | — | WO | disclosed |
| WO-2023217230-A1 | KINESIN KIF18A INHIBITOR AND USE THEREOF | 上海湃隆生物科技有限公司 | 2023-11-16 | — | — | WO | disclosed |