Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KIF18A | Q8NI77 | 13/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | YWHAG | P61981 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22119526 | 0.87 | KIF18A (0.38) | KIF18A | |
| SCHEMBL25712739 | 0.85 | KIF18A (0.41) | KIF18A | |
| SCHEMBL26646192 | 0.85 | KIF18A (0.37) | KIF18A | |
| SCHEMBL30600578 | 0.85 | KIF18A (0.41) | KIF18A | |
| SCHEMBL29858425 | 0.84 | KIF18A (0.53) | CDC7CDK9NPC1KIF18AMAPT | |
| SCHEMBL29578579 | 0.82 | MEN1 (0.40) | NPC1KIF18AKDM4EMEN1KMT2A | |
| SCHEMBL22964565 | 0.82 | MEN1 (0.40) | NPC1KIF18AKDM4EMEN1KMT2A | |
| SCHEMBL22148553 | 0.81 | HTR1A (0.38) | KIF18ACYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL31346931 | 0.81 | TTR (0.36) | KIF18AALDH1A1SMN1; SMN2 | |
| SCHEMBL29371596 | 0.81 | HTR1A (0.38) | KIF18ACYP3A4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707925-A | Compounds as KIF18A inhibitors and uses thereof | 南京圣和药物研发有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119212988-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-119156382-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| WO-2024217348-A1 | KIF18A INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 南京同诺康医药科技有限公司 | 2024-10-24 | — | — | WO | disclosed |
| WO-2024125488-A1 | AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 浙江海正药业股份有限公司 | 2024-06-20 | — | — | WO | disclosed |
| CN-117917405-A | KIF18A protein inhibitors | 杭州邦顺制药有限公司 | 2024-04-23 | — | — | CN | disclosed |
| WO-2024032661-A1 | KIF18A INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2024-02-15 | — | — | WO | disclosed |
| WO-2024022508-A1 | KIF18A INHIBITOR AND USE | 武汉人福创新药物研发中心有限公司 | 2024-02-01 | — | — | WO | disclosed |
| WO-2023217230-A1 | KINESIN KIF18A INHIBITOR AND USE THEREOF | 上海湃隆生物科技有限公司 | 2023-11-16 | — | — | WO | disclosed |