SCHEMBL30748885

SCHEMBL30748885

[2H]C([2H])(O)c1nc(N)c2c(n1)N(c1ccc(OC3CCCCC3)cc1)CC2(C)C

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TNK2 Q07912 2/20 0.33
BTK Q06187 1/20 0.32
ALDH1A1 P00352 2/20 0.32
TSHR P16473 1/20 0.32
ALOX12 P18054 1/20 0.31
ACACB O00763 3/20 0.31
NR1H4 Q96RI1 1/20 0.31
DYRK1A Q13627 1/20 0.31
PARP10 Q53GL7 1/20 0.30
GRM2 Q14416 1/20 0.30
HRH3 Q9Y5N1 1/20 0.30
APP P05067 1/20 0.30
ABL1 P00519 1/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749001 0.83 TDP1 (0.38) ALDH1A1TSHRALOX12APP
SCHEMBL30749122 0.72 TNK2 (0.36) TNK2BTK
SCHEMBL30748936 0.69 CCNE2 (0.41) APP
SCHEMBL30749065 0.68 PDE4A (0.39) ALDH1A1TSHRAPP
SCHEMBL30749128 0.68 CHRM4 (0.40) ALDH1A1TSHRACACBGRM2ABL1
SCHEMBL30748909 0.66 ACACB (0.37) ACACBHRH3
SCHEMBL30748831 0.64 HRH3 (0.36) ALDH1A1TSHRALOX12ACACBHRH3
SCHEMBL30748758 0.61 APP (0.37) APP
SCHEMBL623629 0.60 PARP10 (0.53) BTKALDH1A1TSHRPARP10GRM2
SCHEMBL26012610 0.60 PARP10 (0.53) BTKALDH1A1TSHRPARP10GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT TNK2 1723/4885BTK 1727/4885ALDH1A1 256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.