SCHEMBL30748914

SCHEMBL30748914

CCOC(=O)c1nc(NCc2ccc(OC)cc2)c2c(n1)N(c1ccc(OC3CCCCC3)cc1)CC2(C)C

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC26A6 Q9BXS9 13/20 0.42
CASP3 P42574 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.40
MAPT P10636 1/20 0.40
TP53 P04637 2/20 0.40
PDE4A P27815 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4C Q08493 1/20 0.37
PDE4D Q08499 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749065 0.91 PDE4A (0.39) SMN1; SMN2PDE4APDE4BPDE4CPDE4D
SCHEMBL30748936 0.84 CCNE2 (0.41) MAPTTP53PDE4APDE4BPDE4C
SCHEMBL30749001 0.83 TDP1 (0.38) SMN1; SMN2PDE4APDE4BPDE4CPDE4D
SCHEMBL30748757 0.69 ALDH1A1 (0.41) SMN1; SMN2TP53
SCHEMBL30748721 0.69 CCNE2 (0.43) SMN1; SMN2MAPTTP53
SCHEMBL31691289 0.69 KDM4E (0.41) SMN1; SMN2MAPTTP53
SCHEMBL31691227 0.67 APP (0.40) SMN1; SMN2MAPTTP53
SCHEMBL30748885 0.66 TNK2 (0.33)
SCHEMBL31739634 0.64 MAPT (0.56) SLC26A6SMN1; SMN2MAPT
SCHEMBL31350618 0.63 MAPT (0.58) SLC26A6SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT SLC26A6 2796/4885CASP3 15/4885SMN1; SMN2 38/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.