Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656384 | 0.89 | HDAC1 (0.56) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL9365374 | 0.87 | KMT2A (0.54) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8660104 | 0.85 | MEN1 (0.55) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL9362032 | 0.85 | HDAC1 (0.55) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8891107 | 0.84 | NPC1 (0.54) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8891232 | 0.83 | KMT2A (0.53) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8656388 | 0.83 | ALDH1A1 (0.58) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8659610 | 0.83 | ALDH1A1 (0.58) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8658543 | 0.83 | ALDH1A1 (0.58) | SPHK2NPC1KMT2AMEN1RAB9A | |
| SCHEMBL8659682 | 0.82 | HDAC1 (0.54) | SPHK2NPC1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100310540-A1 | METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE TAFIA ACTIVITY, COMPOUNDS, AND METHODS OF USING THE COMPOUNDS | GREENFIELD ROBERT S | 2010-12-09 | — | — | US | disclosed |
| US-7767646-B2 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds | AMERICAN DIAGNOSTICA, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| EP-1664327-A2 | METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE TAFIa ACTIVITY, COMPOUNDS, AND METHODS OF USING THE COMPOUNDS | AMERICAN DIAGNOSTICA, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080305508-A1 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds | BIOMEDICA DIAGNOSTICS INC. (CA) | 2008-12-11 | — | — | US | disclosed |
| US-20080280920-A1 | Plasminogen Activator Inhibitor-1 Inhibitors | AMERICAN DIAGNOSTICA INC. | 2008-11-13 | — | — | US | disclosed |
| EP-1960395-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS | American Diagnostica Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007065261-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS | AMERICAN DIAGNOSTICA INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| US-7119068-B2 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds | AMERICAN DIAGNOSTICA, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-20050222096-A1 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds | SEKISUI DIAGNOSTICS, LLC | 2005-10-06 | — | — | US | disclosed |
| WO-2004019882-A2 | METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE TAFIa ACTIVITY, COMPOUNDS, AND METHODS OF USING THE COMPOUNDS | AMERICAN DIAGNOSTICA, INC. (US) | 2004-03-11 | — | — | WO | disclosed |
| US-4167581-A | 1-ARYLOXY-3-(ACYLAMINO)ALKYLAMINO-2-PROPANOL ADRENERGIC BLOCKING, AGENTS AND CARDIAC STIMULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-09-11 | — | — | US | disclosed |
| US-4131685-A | ADRENERGIC BLOCKING AGENT, CARDIAC STIMULANT | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280920-A1 | Plasminogen Activator Inhibitor-1 Inhibitors | SERPINE1, SERPINC1, SERPINB1 | SPHK2 3561/4885NPC1 2309/4885KMT2A 4377/4885 |
| US-20100310540-A1 | METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE TAFIA ACTIVITY, COMPOUNDS, AND METHODS OF USING THE COMPOUNDS | TFPI, TFPI2, SERPINC1 | SPHK2 2854/4885NPC1 4663/4885KMT2A 4443/4885 |
| US-20050222096-A1 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds | TFPI, TFPI2, SERPINC1 | SPHK2 2223/4885NPC1 4748/4885KMT2A 4542/4885 |
| US-20080305508-A1 | Methods of screening for compounds that modulate TAFIa activity, compounds, and methods of using the compounds | TFPI, TFPI2, SERPINC1 | SPHK2 2854/4885NPC1 4663/4885KMT2A 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.