Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062642 | 0.94 | PDE4B (0.38) | CHRNB2CHRNA5CHRNA7CHRNA4CYSLTR2 | |
| SCHEMBL3074296 | 0.88 | PDE4B (0.36) | CHRNB2CHRNA5CHRNA7CHRNA4CYSLTR2 | |
| SCHEMBL3087026 | 0.86 | ALDH1A1 (0.40) | PDE4BALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL3084888 | 0.84 | MKNK2 (0.35) | PDE4BKDM1APTGIR | |
| SCHEMBL3072664 | 0.82 | GRM5 (0.40) | CHRNB2CHRNA5CHRNA7CHRNA4PDE4B | |
| SCHEMBL3079434 | 0.81 | PDE4B (0.34) | CYSLTR2CYSLTR1PDE4BKDM1AMAOA | |
| SCHEMBL3072342 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA5CHRNA7CHRNA4PDE4B | |
| SCHEMBL3060248 | 0.81 | REN (0.41) | CYSLTR2CYSLTR1 | |
| SCHEMBL3065913 | 0.77 | MAOB (0.38) | CHRNB2CHRNA5CHRNA7CHRNA4PDE4B | |
| SCHEMBL3070416 | 0.77 | PDE4B (0.37) | CHRNB2CHRNA5CHRNA7CHRNA4PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790715-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-07 | — | — | US | disclosed |
| US-20070010511-A1 | Organic compounds | NOVARTIS PHARMA AG (CH) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010511-A1 | Organic compounds | REN, ACE, ACE2 | CHRNB2 3971/4885CHRNA5 3951/4885CHRNA7 4153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.