Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 0.65 |
| ▸ | DRD2 | P14416 | 18/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 9/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715630 | 0.89 | DRD2 (0.51) | DRD3DRD2HRH1KCNH2HTR1D | |
| SCHEMBL3091220 | 0.86 | DRD3 (0.73) | DRD3DRD2HRH1KCNH2HTR1D | |
| SCHEMBL3086163 | 0.85 | DRD3 (0.59) | DRD3DRD2HRH1KCNH2HTR1D | |
| SCHEMBL3083219 | 0.85 | DRD3 (0.62) | DRD3DRD2HRH1KCNH2HTR2A | |
| SCHEMBL3073465 | 0.84 | DRD3 (0.64) | DRD3DRD2HRH1KCNH2HTR1D | |
| SCHEMBL3087616 | 0.84 | DRD3 (0.61) | DRD3DRD2HRH1KCNH2HTR1D | |
| SCHEMBL3078175 | 0.81 | DRD2 (0.56) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL3080651 | 0.81 | DRD2 (0.56) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL3089494 | 0.81 | DRD3 (0.64) | DRD3DRD2HRH1KCNH2HTR1D | |
| SCHEMBL3080051 | 0.79 | DRD3 (0.50) | DRD3DRD2HRH1HTR1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795437-B2 | Ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | claimed |
| US-20080103174-A1 | ETHER DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-05-01 | — | — | US | claimed |
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | disclosed |
| US-7795437-B2 | Ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20080103174-A1 | ETHER DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103174-A1 | ETHER DERIVATIVES | GABRE, BDNF, ADH1A | DRD3 71/4885DRD2 59/4885HRH1 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.