Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | AKT2 | P31751 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PRKX | P51817 | 2/20 | 0.41 |
| ▸ | NEK4 | P51957 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760184 | 0.88 | MAPK1 (0.51) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760070 | 0.87 | ROCK1 (0.44) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30759993 | 0.82 | DHPS (0.47) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL31407232 | 0.82 | ROCK2 (0.46) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760073 | 0.81 | HDAC4 (0.40) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30759979 | 0.80 | AAK1 (0.41) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760123 | 0.80 | AKT1 (0.39) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL14847725 | 0.79 | GAA (0.48) | TRPA1S1PR3 | |
| SCHEMBL393133 | 0.79 | GAA (0.48) | TRPA1S1PR3 | |
| SCHEMBL30760154 | 0.78 | ROCK2 (0.43) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024040080-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2024-02-22 | — | — | WO | disclosed |