Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRM | P19623 | 1/20 | 0.71 |
| ▸ | SMS | P52788 | 1/20 | 0.71 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.66 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.66 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.66 |
| ▸ | DPP4 | P27487 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.65 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.65 |
| ▸ | GAPDH | P04406 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.65 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.65 |
| ▸ | STAT6 | P42226 | 1/20 | 0.65 |
| ▸ | PI4KA | P42356 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4184440 | 0.98 | DOT1L (0.68) | SRMSMSDOT1LDNMT3BPRMT7 | |
| SCHEMBL996891 | 0.98 | DOT1L (0.68) | SRMSMSDOT1LDNMT3BPRMT7 | |
| SCHEMBL5007882 | 0.97 | SRM (0.67) | SRMSMSDOT1LDNMT3BPRMT7 | |
| SCHEMBL13667507 | 0.89 | EHMT1 (0.74) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL28374784 | 0.89 | EHMT1 (0.74) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL13986406 | 0.88 | ADORA3 (0.73) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL7062240 | 0.88 | ADORA3 (0.73) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL7062257 | 0.88 | ADORA3 (0.73) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL9970116 | 0.87 | DOT1L (0.69) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL15984531 | 0.87 | EHMT1 (0.70) | DOT1LDPP4MEN1SLC28A1MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023249908-A1 | USE OF NON-TOXIC POLYAMINE ANALOGUES AND/OR INHIBITORS OF POLYAMINE BIOSYNTHESIS TO RE-BALANCE NATURAL POLYAMINE LEVELS IN SNYDER-ROBINSON SYNDROME AND RELATED DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-12-28 | — | — | WO | claimed |