Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.68 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.68 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.68 |
| ▸ | SRM | P19623 | 1/20 | 0.68 |
| ▸ | SMS | P52788 | 1/20 | 0.68 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.67 |
| ▸ | GAPDH | P04406 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | PI4KA | P42356 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996891 | 1.00 | DOT1L (0.68) | DOT1LDNMT3BPRMT7SRMSMS | |
| SCHEMBL30760710 | 0.98 | SRM (0.71) | DOT1LDNMT3BPRMT7SRMSMS | |
| SCHEMBL5007882 | 0.95 | SRM (0.67) | DOT1LDNMT3BPRMT7SRMSMS | |
| SCHEMBL28374784 | 0.91 | EHMT1 (0.74) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL13667507 | 0.91 | EHMT1 (0.74) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL13986406 | 0.89 | ADORA3 (0.73) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL7062240 | 0.89 | ADORA3 (0.73) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL7062257 | 0.89 | ADORA3 (0.73) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL17568775 | 0.88 | EHMT1 (0.70) | DOT1LDPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL15984531 | 0.88 | EHMT1 (0.70) | DOT1LDPP4MEN1SLC28A1MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357881-A4 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK PHARMACEUTICALS INC (US) | 2009-02-18 | — | — | EP | claimed |
| US-20040229886-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK BIOTECH, INC. & SHIONOGI CO., LTD. | 2004-11-18 | — | — | US | claimed |
| US-6696454-B2 | ADMINISTERING AN INHIBITOR OF SPERMIDINE BIOSYNTHESIS; PREFERRED ARE DCHA (DICYCLOHEXYLAMINE), ADODATO, AND TRANS-4-METHYLCYCLOHEXYLAMINE (4MCHA) | QUARK BIOTECH, INC. | 2004-02-24 | — | — | US | claimed |
| EP-1357881-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | Quark Biotech, Inc. (US) | 2003-11-05 | — | — | EP | claimed |
| US-20020160978-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | claimed |
| WO-2002058623-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK BIOTECH, INC. (US) | 2002-08-01 | — | — | WO | claimed |
| EP-1357881-A4 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK PHARMACEUTICALS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| US-6696454-B2 | ADMINISTERING AN INHIBITOR OF SPERMIDINE BIOSYNTHESIS; PREFERRED ARE DCHA (DICYCLOHEXYLAMINE), ADODATO, AND TRANS-4-METHYLCYCLOHEXYLAMINE (4MCHA) | QUARK BIOTECH, INC. | 2004-02-24 | — | — | US | disclosed |
| EP-1357881-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | Quark Biotech, Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| US-20020160978-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | disclosed |
| WO-2002058623-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK BIOTECH, INC. (US) | 2002-08-01 | — | — | WO | disclosed |