Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | SPR | P35270 | 4/20 | 0.34 |
| ▸ | NAMPT | P43490 | 4/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20965559 | 0.75 | JAK3 (0.41) | JAK3SPRNAMPTCTSKGRIN2B | |
| SCHEMBL18390381 | 0.75 | JAK3 (0.43) | JAK3SPRNAMPTCTSKGRIN2B | |
| SCHEMBL18711509 | 0.74 | SPR (0.42) | JAK3SPRCTSKGRIN2BGRIN2C | |
| SCHEMBL27374605 | 0.74 | JAK3 (0.43) | JAK3SPRNAMPTCTSKGRIN2B | |
| SCHEMBL20970581 | 0.74 | JAK3 (0.47) | JAK3SPRNAMPTCTSKGRIN2B | |
| SCHEMBL31599783 | 0.74 | USP2 (0.35) | JAK3SPRCTSKGRIN2BGRIN2C | |
| SCHEMBL18390154 | 0.74 | JAK3 (0.46) | JAK3SPRNAMPTCTSKGRIN2B | |
| SCHEMBL18390217 | 0.73 | JAK3 (0.38) | JAK3SPRCTSKGRIN2BGRIN2C | |
| SCHEMBL2225547 | 0.73 | HSD11B1 (0.49) | HSD11B1USP2SMN1; SMN2 | |
| SCHEMBL18701999 | 0.73 | SPR (0.42) | JAK3SPRNAMPTCTSKGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117425649-A | Pyrazole derivatives as KRAS mutein inhibitors | 诺华股份有限公司 | 2024-01-19 | — | — | CN | disclosed |