Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 8/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 7/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30762573 | 0.81 | HTT (0.50) | ATRATRIPCRHBPCRHR2KMT2A | |
| SCHEMBL30762595 | 0.79 | ATR (0.46) | ATRATRIPKDM4EGAAALDH1A1 | |
| SCHEMBL30762545 | 0.77 | PIK3CA (0.62) | PIK3CB | |
| SCHEMBL30808207 | 0.75 | MET (0.44) | ATRCRHBPCRHR2KMT2AKDM4E | |
| SCHEMBL23299953 | 0.74 | KMT2A (0.56) | CRHBPCRHR2KMT2AKDM4EGAA | |
| SCHEMBL30784478 | 0.74 | AKT1 (0.44) | PIK3CB | |
| SCHEMBL30783583 | 0.73 | AKT1 (0.47) | KMT2APIK3CB | |
| SCHEMBL30783648 | 0.73 | KMT2A (0.44) | KMT2AGAAPIK3CBALDH1A1HPGD | |
| SCHEMBL30784348 | 0.73 | AKT1 (0.47) | KMT2APIK3CB | |
| SCHEMBL30783689 | 0.72 | PIK3CB (0.39) | PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026423-A1 | SUBSTITUTED QUINOLINE DERIVATIVES AS PI3K INHIBITORS | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |