Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30762368 | 0.88 | GSK3A (0.39) | CFTRATMLRRK2 | |
| SCHEMBL30762645 | 0.88 | GSK3A (0.39) | CFTRATMLRRK2 | |
| SCHEMBL30762357 | 0.76 | ALDH1A1 (0.52) | KDM4EPOLBHTTATMTDP1 | |
| SCHEMBL25544660 | 0.75 | CFTR (0.33) | KDM4ELMNASMN1; SMN2PARP14CFTR | |
| SCHEMBL30762571 | 0.74 | PARP14 (0.41) | PARP14CFTRACHEELANEALDH1A1 | |
| SCHEMBL30762503 | 0.74 | CHRM4 (0.36) | PARP14IRAK4ACHE | |
| SCHEMBL30762548 | 0.74 | RAPGEF4 (0.31) | HTTSOS1RAPGEF4ALDH1A1HPGD | |
| SCHEMBL30762422 | 0.74 | RXFP1 (0.34) | KDM4ECFTRRAPGEF4LRRK2ALDH1A1 | |
| SCHEMBL30762491 | 0.72 | CFTR (0.43) | KDM4ECFTR | |
| SCHEMBL30762580 | 0.72 | PKM (0.32) | CFTRIRAK4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026423-A1 | SUBSTITUTED QUINOLINE DERIVATIVES AS PI3K INHIBITORS | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |