Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765185 | 0.89 | GLRA1 (0.44) | NPC1NAMPT | |
| SCHEMBL30765295 | 0.89 | GLRA1 (0.44) | NPC1NAMPT | |
| SCHEMBL30765337 | 0.86 | NPC1 (0.49) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL30765343 | 0.85 | TSHR (0.47) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL723467 | 0.84 | HPGD (0.48) | NPC1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30765370 | 0.83 | HSD11B1 (0.39) | NPC1ALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL30765178 | 0.80 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL27263347 | 0.80 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL27263346 | 0.80 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL30765379 | 0.80 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |