Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 16/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.41 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260728 | 0.89 | BRD4 (0.49) | PIK3CGPIK3CAPIK3CDPIK3C3PIK3CB | |
| SCHEMBL30765170 | 0.86 | LOXL2 (0.41) | PIK3CGPIK3CAPIK3CDPIK3CBIKBKB | |
| SCHEMBL27260716 | 0.86 | LOXL2 (0.41) | PIK3CGPIK3CAPIK3CDPIK3CBIKBKB | |
| SCHEMBL27260886 | 0.86 | PIK3CD (0.48) | PIK3CGPIK3CAPIK3CDPIK3C3PIK3CB | |
| SCHEMBL30765392 | 0.86 | PIK3CG (0.44) | PIK3CGPIK3CAPIK3CDPIK3C3PIK3CB | |
| SCHEMBL30765299 | 0.84 | IRAK1 (0.41) | PIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL27260895 | 0.84 | PIK3CD (0.47) | PIK3CGPIK3CAPIK3CDPIK3C3PIK3CB | |
| SCHEMBL27260617 | 0.83 | KCNH2 (0.47) | PIK3CD | |
| SCHEMBL27260812 | 0.80 | IRAK1 (0.36) | PIK3CGPIK3CA | |
| SCHEMBL27260725 | 0.80 | KCNH2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |