Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 6/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260716 | 1.00 | LOXL2 (0.41) | LOXL2BRD4IRAK4TDO2PIK3CG | |
| SCHEMBL27260728 | 0.92 | BRD4 (0.49) | LOXL2BRD4IRAK4PIK3CGPIK3CD | |
| SCHEMBL30765282 | 0.86 | PIK3CG (0.49) | PIK3CGPIK3CDPIK3CBIKBKBCHUK | |
| SCHEMBL27260617 | 0.84 | KCNH2 (0.47) | LOXL2BRD4PIK3CDTTKMAPK8 | |
| SCHEMBL30765299 | 0.84 | IRAK1 (0.41) | BRD4IRAK4PIK3CGPIK3CDPIK3CB | |
| SCHEMBL27260725 | 0.81 | KCNH2 (0.40) | LOXL2BRD4IRAK4TTKMAPK8 | |
| SCHEMBL724751 | 0.81 | MAP3K7 (0.47) | LOXL2BRD4PIK3CDTTKMAPK8 | |
| SCHEMBL30765309 | 0.78 | ACVR1 (0.41) | LOXL2BRD4IRAK4TDO2PIK3CD | |
| SCHEMBL30765283 | 0.78 | IRAK4 (0.38) | LOXL2BRD4IRAK4TTKMAPK8 | |
| SCHEMBL27260809 | 0.78 | IRAK4 (0.38) | LOXL2BRD4IRAK4TTKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |