Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 3/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260728 | 0.87 | BRD4 (0.49) | IRAK1PIK3CGPIK3CDPIK3CBBRD4 | |
| SCHEMBL30765282 | 0.84 | PIK3CG (0.49) | PIK3CGPIK3CDPIK3CBPIK3CA | |
| SCHEMBL30765170 | 0.84 | LOXL2 (0.41) | IRAK1PIK3CGPIK3CDPIK3CBBRD4 | |
| SCHEMBL27260716 | 0.84 | LOXL2 (0.41) | IRAK1PIK3CGPIK3CDPIK3CBBRD4 | |
| SCHEMBL30765338 | 0.79 | RET (0.45) | IRAK1PIK3CARETTGFBR1 | |
| SCHEMBL27260617 | 0.78 | KCNH2 (0.47) | PIK3CDBRD4 | |
| SCHEMBL722232 | 0.76 | IRAK1 (0.40) | IRAK1GSK3BDYRK1ARETTGFBR1 | |
| SCHEMBL27260725 | 0.75 | KCNH2 (0.40) | IRAK1BRD4IRAK4 | |
| SCHEMBL724751 | 0.74 | MAP3K7 (0.47) | IRAK1PIK3CDBRD4AURKB | |
| SCHEMBL30765283 | 0.74 | IRAK4 (0.38) | IRAK1BRD4IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |