Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 7/20 | 0.48 |
| ▸ | RARB | P10826 | 7/20 | 0.48 |
| ▸ | RARG | P13631 | 7/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765288 | 0.88 | MAPT (0.39) | RARARARBRARGKDM4ENPC1 | |
| SCHEMBL18339379 | 0.84 | CYP1A2 (0.40) | RARARARBRARGKDM4ETDP1 | |
| SCHEMBL30765301 | 0.84 | TNKS (0.45) | TNKSKDM4ETDP1NPC1RAB9A | |
| SCHEMBL18339400 | 0.84 | TNKS (0.45) | TNKSKDM4ETDP1NPC1RAB9A | |
| SCHEMBL15209535 | 0.83 | RARA (0.39) | RARARARBRARGKMORXRA | |
| SCHEMBL722060 | 0.82 | CYP1A1 (0.47) | TNKSKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL15173516 | 0.81 | RAB9A (0.48) | RARARARBRARGTNKSKDM4E | |
| SCHEMBL723467 | 0.81 | HPGD (0.48) | NPC1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL721875 | 0.80 | CSNK2A2 (0.40) | MAPKAPK2TNKSKDM4ENPC1RAB9A | |
| SCHEMBL724007 | 0.80 | MAPK14 (0.43) | TNKSKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |