Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.38 |
| ▸ | RARG | P13631 | 4/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765382 | 0.88 | RARA (0.48) | MAPTRARARARBRARGSMN1; SMN2 | |
| SCHEMBL18339379 | 0.86 | CYP1A2 (0.40) | TP53RARARARBRARGALDH1A1 | |
| SCHEMBL18339400 | 0.86 | TNKS (0.45) | MAPTTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30765301 | 0.86 | TNKS (0.45) | MAPTTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10268108 | 0.85 | CTSB (0.40) | MAPTRXFP1TP53PRKAB2PRKAG1 | |
| SCHEMBL18348148 | 0.83 | HSD17B1 (0.36) | MAPTRXFP1RARARARBRARG | |
| SCHEMBL15173516 | 0.83 | RAB9A (0.48) | MAPTRARARARBRARGSMN1; SMN2 | |
| SCHEMBL721875 | 0.81 | CSNK2A2 (0.40) | MAPTTP53SMN1; SMN2ALDH1A1ESR1 | |
| SCHEMBL18348188 | 0.81 | TYK2 (0.34) | RXFP1RARARARBRARG | |
| SCHEMBL18348161 | 0.80 | ALDH1A1 (0.36) | MAPTRXFP1RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |