Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 7/20 | 0.35 |
| ▸ | KDR | P35968 | 7/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.35 |
| ▸ | FLT1 | P17948 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28477039 | 0.91 | TDP1 (0.39) | TDP1MAPK1ALDH1A1CYP3A4APP | |
| SCHEMBL31558424 | 0.83 | APP (0.34) | APPERBB2EPHA2KDREPHB4 | |
| SCHEMBL18589288 | 0.80 | BCHE (0.48) | TDP1ALDH1A1TSHRERBB2EPHA2 | |
| SCHEMBL18582506 | 0.80 | BCHE (0.48) | TDP1ALDH1A1TSHRERBB2EPHA2 | |
| SCHEMBL30765561 | 0.80 | CA2 (0.44) | ERBB2EPHA2KDREPHB4FLT1 | |
| SCHEMBL31558434 | 0.77 | ALDH1A1 (0.40) | MAPK1ALDH1A1CYP3A4APPBCHE | |
| SCHEMBL14713886 | 0.75 | LMNA (0.43) | TDP1MAPK1ALDH1A1BCHEMAPT | |
| SCHEMBL14713885 | 0.75 | LMNA (0.43) | TDP1MAPK1ALDH1A1BCHEMAPT | |
| SCHEMBL22604496 | 0.75 | CA1 (0.43) | — | |
| SCHEMBL18589290 | 0.75 | BCHE (0.51) | BCHEMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568666-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Alexion Pharmaceuticals, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| CN-119768164-A | Pharmaceutical compounds for treating complement-mediated disorders | 阿雷克森制药公司 | 2025-04-04 | — | — | CN | disclosed |
| WO-2024035686-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2024-02-15 | — | — | WO | disclosed |