Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 7/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 5/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25076302 | 0.80 | S1PR1 (0.36) | HSD11B1S1PR1S1PR5 | |
| SCHEMBL18566778 | 0.74 | APLNR (0.39) | CYP1A2KMT2A | |
| SCHEMBL4957925 | 0.73 | SLC6A11 (0.48) | SLC6A11SLC6A12MEN1TP53CYP1A2 | |
| SCHEMBL4960236 | 0.73 | SLC6A11 (0.48) | SLC6A11SLC6A12MEN1TP53CYP1A2 | |
| SCHEMBL4957931 | 0.73 | SLC6A11 (0.48) | SLC6A11SLC6A12MEN1TP53CYP1A2 | |
| SCHEMBL20683622 | 0.71 | GBA1 (0.35) | HSD11B1GBA1 | |
| SCHEMBL9949510 | 0.71 | SLC6A11 (0.58) | SLC6A11SLC6A12MEN1TP53CYP1A2 | |
| SCHEMBL9949505 | 0.71 | SLC6A11 (0.58) | SLC6A11SLC6A12MEN1TP53CYP1A2 | |
| SCHEMBL23227044 | 0.70 | GBA1 (0.47) | HSD11B1GBA1SLC6A11SLC6A12MEN1 | |
| SCHEMBL25076300 | 0.70 | BRD4 (0.35) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568960-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| CN-119677733-A | Bicyclic tetrahydrothiazepine derivatives | 豪夫迈·罗氏有限公司 | 2025-03-21 | — | — | CN | disclosed |
| WO-2024033458-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | disclosed |