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SCHEMBL30767447

SCHEMBL30767447

CC(C)(C)OC(=O)N[C@@H]1CC(F)(F)c2cc(F)c(-c3nnc(C(C)(C)S(C)(=O)=O)o3)cc2N(Cc2ccc(-c3ccc(C(F)(F)F)cn3)cc2)C1=O

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ FPR2 P25090 2/20 0.32
▸ GPR119 Q8TDV5 1/20 0.31
▸ ALOX5AP P20292 1/20 0.31
▸ FEN1 P39748 1/20 0.31
▸ RORC P51449 1/20 0.31
▸ FPR1 P21462 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30767535 1.00 FPR2 (0.32) FPR2GPR119ALOX5APFEN1RORC
SCHEMBL30767430 1.00 FPR2 (0.32) FPR2GPR119ALOX5APFEN1RORC
SCHEMBL30767484 0.94 MDM2 (0.33) FPR2RORC
SCHEMBL30767579 0.94 MDM2 (0.33) FPR2RORC
SCHEMBL30767584 0.94 MDM2 (0.33) FPR2RORC
SCHEMBL30767514 0.93 CHRM5 (0.34) GPR119ALOX5APFEN1
SCHEMBL30767442 0.93 CHRM5 (0.34) GPR119ALOX5APFEN1
SCHEMBL30767557 0.93 CHRM5 (0.34) GPR119ALOX5APFEN1
SCHEMBL30767526 0.92 GPR119 (0.31) GPR119ALOX5APFEN1
SCHEMBL30767423 0.92 GPR119 (0.31) GPR119ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568960-A1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2025-06-18 — — EP disclosed
WO-2024033458-A1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2024-02-15 — — WO disclosed
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