Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.59 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.59 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31487408 | 0.94 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30965512 | 0.94 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30830715 | 0.94 | DDB1 (0.58) | DDB1CRBNGPR119CYP3A4USP2 | |
| SCHEMBL30831087 | 0.93 | DDB1 (0.51) | DDB1CRBNGPR119CYP3A4USP2 | |
| SCHEMBL21876868 | 0.92 | DDB1 (0.63) | DDB1CRBNGPR119 | |
| SCHEMBL29680886 | 0.89 | DDB1 (0.60) | DDB1CRBNGPR119CYP3A4MEN1 | |
| SCHEMBL31726711 | 0.89 | DDB1 (0.60) | DDB1CRBNGPR119CYP3A4MEN1 | |
| SCHEMBL31607945 | 0.88 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30830671 | 0.87 | DDB1 (0.61) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30830803 | 0.86 | DDB1 (0.54) | DDB1CRBNGPR119CYP3A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |