Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768973 | 0.93 | DDB1 (0.59) | DDB1CRBNGPR119CYP3A4USP2 | |
| SCHEMBL30830936 | 0.90 | DDB1 (0.52) | DDB1CRBNGPR119CYP3A4MAPK1 | |
| SCHEMBL30831091 | 0.88 | DDB1 (0.47) | DDB1CRBNGPR119CYP3A4USP2 | |
| SCHEMBL31487408 | 0.87 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30965512 | 0.87 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30830715 | 0.87 | DDB1 (0.58) | DDB1CRBNGPR119CYP3A4USP2 | |
| SCHEMBL21876868 | 0.85 | DDB1 (0.63) | DDB1CRBNGPR119 | |
| SCHEMBL30768407 | 0.84 | CRBN (0.55) | DDB1CRBNCYP3A4USP2HSD17B10 | |
| SCHEMBL30830863 | 0.83 | DDB1 (0.51) | DDB1CRBNGPR119 | |
| SCHEMBL31726711 | 0.82 | DDB1 (0.60) | DDB1CRBNGPR119CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |