Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768973 | 0.94 | DDB1 (0.59) | DDB1CRBNGPR119HSD17B10ALDH1A1 | |
| SCHEMBL30965512 | 0.93 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL31487408 | 0.93 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL30830671 | 0.92 | DDB1 (0.61) | DDB1CRBNGPR119USP30 | |
| SCHEMBL21876868 | 0.90 | DDB1 (0.63) | DDB1CRBNGPR119 | |
| SCHEMBL30831066 | 0.89 | DDB1 (0.59) | DDB1CRBNGPR119HSD17B10ALDH1A1 | |
| SCHEMBL30831087 | 0.87 | DDB1 (0.51) | DDB1CRBNGPR119HSD17B10ALDH1A1 | |
| SCHEMBL31607945 | 0.85 | DDB1 (0.58) | DDB1CRBNGPR119USP30 | |
| SCHEMBL31726780 | 0.84 | DDB1 (0.58) | DDB1CRBNGPR119 | |
| SCHEMBL25031342 | 0.84 | DDB1 (0.58) | DDB1CRBNGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |