Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 13/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993 | 0.99 | LTB4R2 (0.45) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL2375 | 0.91 | LTB4R2 (0.49) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL3423 | 0.90 | LTB4R2 (0.49) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL8485020 | 0.83 | LTB4R2 (0.41) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8485466 | 0.83 | LTB4R2 (0.42) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL2318 | 0.81 | ACHE (0.44) | LTB4R2AGTR1 | |
| SCHEMBL682687 | 0.81 | AGTR1 (0.47) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL3575 | 0.80 | ACHE (0.44) | LTB4R2AGTR1 | |
| SCHEMBL2864 | 0.80 | AGTR1 (0.47) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL3104 | 0.79 | AGTR1 (0.50) | LTB4R2AGTR1ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |