Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385678 | 1.00 | KDM4E (0.48) | KDM4EKMT2AGRM5KDM6BKDM4A | |
| SCHEMBL30761191 | 0.86 | IKBKB (0.49) | KDM4EKMT2AGRM5NPC1TP53 | |
| SCHEMBL20773709 | 0.84 | L3MBTL1 (0.46) | KDM4EGRM5NPC1TP53HPGD | |
| SCHEMBL30775039 | 0.84 | L3MBTL1 (0.46) | KDM4EGRM5NPC1TP53HPGD | |
| SCHEMBL6342333 | 0.83 | LMNA (0.50) | KDM4EKMT2AKDM6BKDM4AKDM5C | |
| SCHEMBL264270 | 0.82 | HCRTR2 (0.50) | KDM4EHCRTR1HCRTR2ALDH1A1L3MBTL1 | |
| SCHEMBL30775045 | 0.82 | HCRTR2 (0.50) | KDM4EHCRTR1HCRTR2ALDH1A1L3MBTL1 | |
| SCHEMBL7911678 | 0.82 | CCR1 (0.50) | KDM4EGRM5HPGDRAB9AALDH1A1 | |
| Lithium SCHEMBL607039 | 0.81 | HCRTR2 (0.49) | KDM4EHCRTR1HCRTR2ALDH1A1L3MBTL1 | |
| SCHEMBL3389125 | 0.81 | KDM4E (0.49) | KDM4EHCRTR1HCRTR2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688155-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | Bial-Portela & CA, S.A. (PT) | 2026-02-11 | — | — | EP | disclosed |
| WO-2025023852-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - PORTELA & CA., S.A. (PT) | 2025-01-30 | — | — | WO | disclosed |
| CN-111315734-B | Substituted 2-azabicyclo [3.1.1] heptane and 2-azabicyclo [3.2.1] octane derivatives as orexin receptor antagonists | 克罗诺斯治疗有限公司 | 2024-03-08 | — | — | CN | disclosed |