Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2777384 | 0.90 | MKNK1 (0.54) | CHRNB2CHRNA4MKNK1MKNK2CHEK1 | |
| SCHEMBL30775410 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4CHEK1PRKCZCHUK | |
| SCHEMBL30775350 | 0.81 | CHRNB2 (0.70) | CHRNB2CHRNA4MKNK1MKNK2PRKCZ | |
| SCHEMBL7889387 | 0.77 | CHRNB2 (0.54) | CHRNB2CHRNA4PRKCZCHRM2CHRM1 | |
| SCHEMBL4102786 | 0.77 | CHRNB2 (0.54) | CHRNB2CHRNA4PRKCZCHRM2CHRM1 | |
| SCHEMBL6307787 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNA4MKNK1MKNK2PRKCZ | |
| SCHEMBL2267256 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNA4MKNK1MKNK2PRKCZ | |
| SCHEMBL6306148 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNA4MKNK1MKNK2PRKCZ | |
| SCHEMBL30775431 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNA4MKNK1MKNK2PRKCZ | |
| Hydrochloric Acid SCHEMBL7470431 | 0.76 | CHRNB2 (0.97) | CHRNB2CHRNA4MKNK1MKNK2PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | claimed |
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | DONG-A ST CO., LTD. (KR) | 2025-03-04 | — | — | US | disclosed |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | EIF2AK4, GCN1, GCGR | CHRNB2 3816/4885CHRNA4 4788/4885MKNK1 441/4885 |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EIF2AK4, GCN1, GCGR | CHRNB2 3816/4885CHRNA4 4788/4885MKNK1 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.