Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.46 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264859 | 0.75 | CHRNB2 (0.53) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| SCHEMBL2269304 | 0.75 | CHRNB2 (0.53) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| SCHEMBL3655274 | 0.75 | CHRNB2 (0.53) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| SCHEMBL29994416 | 0.75 | CHRNB2 (0.53) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| SCHEMBL31234233 | 0.75 | CHRNB2 (0.53) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| SCHEMBL7464016 | 0.75 | PAICS (0.48) | CHRNB2CHRNA4SYKHRH1MKNK1 | |
| Hydrochloric Acid SCHEMBL31656540 | 0.74 | CHRNB2 (0.51) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| Hydrochloric Acid SCHEMBL28668620 | 0.74 | CHRNB2 (0.51) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| Hydrochloric Acid SCHEMBL22031566 | 0.74 | CHRNB2 (0.51) | HTR2CHTR2BCHRNB2CHRNA4HRH1 | |
| Hydrochloric Acid SCHEMBL1953011 | 0.74 | CHRNB2 (0.51) | HTR2CHTR2BCHRNB2CHRNA4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | DONG-A ST CO., LTD. (KR) | 2025-03-04 | — | — | US | disclosed |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | EIF2AK4, GCN1, GCGR | NPC1 89/4885CYP1A2 1905/4885CYP2C9 1949/4885 |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EIF2AK4, GCN1, GCGR | NPC1 89/4885CYP1A2 1905/4885CYP2C9 1949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.