Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697735 | 1.00 | PRKCI (0.49) | PRKCICYP2A6HTR6PIK3CBL3MBTL1 | |
| SCHEMBL22076877 | 0.83 | TFPI2 (0.38) | PRKCIHTR6ALDH1A1KDM4E | |
| SCHEMBL398452 | 0.78 | PRKCI (0.70) | PRKCICYP2A6HTR6PIK3CBL3MBTL1 | |
| SCHEMBL5718697 | 0.78 | PRKCI (0.70) | PRKCICYP2A6HTR6PIK3CBL3MBTL1 | |
| SCHEMBL29507010 | 0.78 | PRKCI (0.70) | PRKCICYP2A6HTR6PIK3CBL3MBTL1 | |
| SCHEMBL2992329 | 0.78 | ALDH1A1 (0.52) | ALDH1A1KDM4EMEN1LMNAMAPT | |
| SCHEMBL26697740 | 0.78 | ALDH1A1 (0.43) | CYP2A6ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL22076838 | 0.77 | KDR (0.36) | PRKCIHTR6PIK3CBKDREGFR | |
| SCHEMBL28286771 | 0.77 | GAA (0.57) | CYP2A6ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL24168132 | 0.77 | BRD4 (0.38) | PRKCIL3MBTL1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118459485-A | Amino-substituted heterocycles for the treatment of cancers with EGFR mutations | 纽威伦特公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-117500803-A | Amino-substituted heterocycles for the treatment of cancers with EGFR mutations | 纽威伦特公司 | 2024-02-02 | — | — | CN | disclosed |