Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | EPOR | P19235 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | PAM | P19021 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3085607 | 0.88 | ESRRG (0.33) | ALDH1A1KDM4EPOLBKMT2ATSHR | |
| SCHEMBL13680106 | 0.76 | TDP1 (0.42) | TDP1ALDH1A1NPSR1NPC1POLB | |
| SCHEMBL202173 | 0.75 | TDP1 (0.50) | TDP1ALDH1A1NPSR1NPC1POLB | |
| SCHEMBL11266811 | 0.75 | RAB9A (0.43) | TDP1ALDH1A1KDM4ENPSR1POLB | |
| SCHEMBL2985617 | 0.75 | NPSR1 (0.42) | TDP1ALDH1A1KDM4EUSP2NPSR1 | |
| SCHEMBL3212653 | 0.74 | TDP1 (0.42) | TDP1EPORKDM4EKMT2ATSHR | |
| SCHEMBL7559996 | 0.74 | TDP1 (0.42) | TDP1EPORKDM4EKMT2ATSHR | |
| SCHEMBL547411 | 0.72 | TDP1 (0.47) | TDP1ALDH1A1NPSR1NPC1POLB | |
| SCHEMBL11729646 | 0.72 | TDP1 (0.47) | TDP1ALDH1A1NPSR1NPC1POLB | |
| Allylamine SCHEMBL11354244 | 0.70 | RAB9A (0.40) | TDP1ALDH1A1KDM4EHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100247463-A1 | N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE | YU RUEY J | 2010-09-30 | — | — | US | disclosed |
| US-7776844-B2 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use | YU RUEY J | 2010-08-17 | — | — | US | disclosed |
| US-20090208499-A1 | N-(Phosphonoalkyl)-Amino Acids, Derivatives Thereof and Compositions and Methods of Use | YU RUEY J | 2009-08-20 | — | — | US | disclosed |
| US-7572776-B2 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use | YU RUEY J | 2009-08-11 | — | — | US | disclosed |
| US-20080306025-A1 | N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE | YU RUEY J | 2008-12-11 | — | — | US | disclosed |
| EP-1979366-A2 | N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE | Yu, Ruey J. (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7429575-B2 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use | YU RUEY J | 2008-09-30 | — | — | US | disclosed |
| WO-2007082206-A2 | N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE | YU RUEY J (US) | 2007-07-19 | — | — | WO | disclosed |
| US-20070161543-A1 | N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE | YU RUEY J | 2007-07-12 | — | — | US | disclosed |
| US-5385895-A | Nervous system disorders, anticonvulsants, analgesics | CORDI ALEXIS A (US) | 1995-01-31 | — | — | US | disclosed |
| US-5177240-A | Treatment to reduce neurotoxic injury | G. D. SEARLE & CO. (US) | 1993-01-05 | — | — | US | disclosed |
| US-4997821-A | Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury | G.D. SEARLE & CO. | 1991-03-05 | — | — | US | disclosed |
| EP-0364996-A2 | Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury | G.D. Searle & Co. (US) | 1990-04-25 | — | — | EP | disclosed |