Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | GLS | O94925 | 4/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30779406 | 1.00 | GPR119 (0.45) | GPR119GLSIDO1TDO2PIK3CD | |
| SCHEMBL30779497 | 1.00 | GPR119 (0.45) | GPR119GLSIDO1TDO2PIK3CD | |
| SCHEMBL30779678 | 0.92 | NR1H2 (0.42) | GPR119GLSFAAHACKR3USP30 | |
| SCHEMBL30779423 | 0.79 | DRD2 (0.40) | KDM4E | |
| SCHEMBL30779498 | 0.78 | HRH3 (0.42) | GPR119 | |
| SCHEMBL25189343 | 0.78 | GPR119 (0.53) | GPR119IDO1TDO2PIK3CDKDM4E | |
| SCHEMBL30234556 | 0.78 | GPR119 (0.53) | GPR119IDO1TDO2PIK3CDKDM4E | |
| SCHEMBL14164236 | 0.78 | GPR119 (0.48) | GPR119KDM4E | |
| SCHEMBL23791421 | 0.77 | GPR119 (0.55) | GPR119IDO1TDO2PIK3CDFAAH | |
| SCHEMBL8618357 | 0.77 | GLS (0.48) | GPR119GLSFAAHKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4573092-A1 | 2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER | Olema Pharmaceuticals, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024039860-A1 | 2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER | OLEMA PHARMACEUTICALS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |