SCHEMBL30782855

SCHEMBL30782855

CC(C)(C)OC(=O)NC[C@@H]1CCOc2c(-c3ccc(C#N)cc3)cccc21

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.37
JAK3 P52333 1/20 0.37
PTK2 Q05397 1/20 0.37
CYP11B1 P15538 2/20 0.36
CYP11B2 P19099 2/20 0.36
CHRM3 P20309 1/20 0.36
EGLN2 Q96KS0 2/20 0.35
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
KDM4C Q9H3R0 2/20 0.35
RORC P51449 3/20 0.35
ACACB O00763 2/20 0.35
GPR119 Q8TDV5 1/20 0.35
PTPN1 P18031 1/20 0.35
KDM4D Q6B0I6 1/20 0.34
ACACA Q13085 1/20 0.34
DRD2 P14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30782916 1.00 JAK2 (0.37) JAK2JAK3PTK2CYP11B1CYP11B2
SCHEMBL29923328 0.86 ACACB (0.43) KDM4CACACBGPR119ACACA
SCHEMBL29923261 0.86 ACACB (0.43) KDM4CACACBGPR119ACACA
SCHEMBL29923405 0.83 CKS1B (0.40) KDM4CACACBACACA
SCHEMBL29923093 0.83 CKS1B (0.37) KDM4CACACBACACADRD2
SCHEMBL30782831 0.83 GPR119 (0.36) JAK2JAK3PTK2CYP11B1CYP11B2
SCHEMBL30782832 0.83 GPR119 (0.36) JAK2JAK3PTK2CYP11B1CYP11B2
SCHEMBL29923494 0.82 ACACB (0.38) KDM4CACACBGPR119ACACADRD2
SCHEMBL29923202 0.82 CKS1B (0.39) KDM4CACACBACACADRD2
SCHEMBL29923308 0.82 KDM4C (0.40) KDM4CACACBKDM4DACACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388558-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER CORETERRA THERAPEUTICS INC (US) 2025-12-25 US disclosed
US-20250304546-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER CORETERRA THERAPEUTICS, INC. 2025-10-02 US disclosed
EP-4593954-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER PGI Drug Discovery LLC (US) 2025-08-06 EP disclosed
US-20250243173-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER CORETERRA THERAPEUTICS, INC. 2025-07-31 US disclosed
US-20250236602-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER CORETERRA THERAPEUTICS, INC. 2025-07-24 US disclosed
US-20250129035-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER CORETERRA THERAPEUTICS, INC. 2025-04-24 US disclosed
WO-2024073383-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER PGI DRUG DISCOVERY LLC (US) 2024-04-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250129035-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER PMP22, INA, SLC18A2 JAK2 887/4885JAK3 1259/4885PTK2 3783/4885
US-20250236602-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER PMP22, INA, SLC18A2 JAK2 887/4885JAK3 1259/4885PTK2 3783/4885
US-20250304546-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER PMP22, INA, SLC18A2 JAK2 887/4885JAK3 1259/4885PTK2 3783/4885
US-20250243173-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER PMP22, INA, SLC18A2 JAK2 887/4885JAK3 1259/4885PTK2 3783/4885
US-20250388558-A1 COMPOUNDS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM DISEASE OR DISORDER GRIN2C, SLC6A1, CLIC1 JAK2 1371/4885JAK3 1566/4885PTK2 2940/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.