SCHEMBL30786295

SCHEMBL30786295

COc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.59
ALDH1A1 P00352 2/20 0.57
LDHA P00338 1/20 0.54
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
KDM4E B2RXH2 1/20 0.52
PKM P14618 1/20 0.52
PTGS2 P35354 3/20 0.52
PTGS1 P23219 1/20 0.51
AGTR1 P30556 2/20 0.49
AGTR2 P50052 2/20 0.49
ACLY P53396 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30786304 0.88 ALDH1A1 (0.75) XDHALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL30676033 0.81 KDM4E (0.54) XDHALDH1A1MEN1KMT2AKDM4E
SCHEMBL26926475 0.81 KDM4E (0.54) XDHALDH1A1MEN1KMT2AKDM4E
SCHEMBL8171724 0.77 XDH (0.69) XDHALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL26926157 0.77 ALDH1A1 (0.44) XDHALDH1A1MEN1KMT2A
SCHEMBL30786310 0.77 ALDH1A1 (0.44) XDHALDH1A1MEN1KMT2A
SCHEMBL3396645 0.77 XDH (0.77) XDHALDH1A1LDHAMEN1KMT2A
SCHEMBL9182513 0.76 ALDH1A1 (0.56) XDHALDH1A1LDHAMEN1KMT2A
SCHEMBL25129319 0.75 PTGS2 (0.63) PTGS2PTGS1
SCHEMBL31074324 0.75 PTGS2 (0.63) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023237015-A1 N-TETRAZOLYL ARYL UREA DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF 杭州壹瑞医药科技有限公司 2023-12-14 WO disclosed